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Migraine Blue - The Goal Is To Be Free of Migraine

Migraineblue is my life now.My goal is to be migraine free.To be be able to be outside and look up at the sky the way I used to,with joy,not fear. To be free to live.

Migraine Blue

Chronic Migraine and Your Health

March 8th 2010 04:01

Poor Health with Chronic Migraine

I have Chronic Migraine. I have found a short article at migraine monitor which I will post a link to here.
My migraine disease has progressed to chronic migraine over the years,going from really over 30 years ago,not knowing it was migraine without pain,to migraine attacks that sent me to the ER
passing out,vomiting,convulsing. To being homebound for over four years,not even being able to look out of the window of my house.
I had a short time period of about 4 months of low level pain. I was excited to get behind the wheel of a car again, being able to swim every day, participate in family events. The simple little things become giant accomplishments. I took none for granted.
Then, things started to go backward. I am not nearly as bad as I was...but my limitations are growing and I am filled with fear of the pain putting me in isolation again.
I have pain that is constant,right now I could scream with the pain and inside I am...I am so tired,I am fighting this,but losing more and more battles.
There is nothing that helps me. I do take time for quiet,prayer,visualization. Depression,well,I am trying to fight that...hard enough as it runs in my family anyway. I get the auras,all this scares me,as the studies show how migraine with aura increases your chances of stroke,which also run in my family.
Tired,worn out,sad and scared.

Take a look at this link
Really Long Link

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Posted By: Marjorie Farrington - Category: No Category

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SUMAVEL(TM) DosePro(TM) Available In The United States

February 26th 2010 22:38

I saw this article about a new treatment for acute migraine and cluster headaches. I wanted to let people know about it, I know I'm going to ask my doctor about it.
When I see an announcement about a new treatment, I feel it's important to pass it along. If anyone's tried this, I'd love comments on the results.

15 Jan 2010 Medical News Today

Zogenix, Inc. ("Zogenix"), a privately held pharmaceutical company, and Astellas Pharma U.S., Inc. ("Astellas") announced the U.S. commercial launch of SUMAVEL™ DosePro™ (sumatriptan injection) needle-free delivery system. In July 2009, the U.S. Food and Drug Administration approved SUMAVEL DosePro for the acute treatment of migraine, with or without aura, and the acute treatment of cluster headaches. SUMAVEL DosePro delivers subcutaneous sumatriptan, a treatment that provides migraine relief starting within 10 minutes for some patients, in a first-of-its-kind needle-free delivery system. SUMAVEL DosePro is expected to be available at most retail pharmacy outlets this month.

"Migraines can be disabling, with profound implications on quality of life," said Roger K. Cady, M.D., vice president of the National Headache Foundation board of directors and director of the Headache Care Center in Springfield, Mo. "One of the most common complaints of my migraine patients is that they would like to achieve faster relief. The availability of SUMAVEL DosePro makes it possible for patients to benefit from the fast relief of a subcutaneous formulation in a simple to use, needle-free delivery system."
UMAVEL DosePro offers other practical benefits. Approximately 30 percent of patients report vomiting as a symptom of migraine attacks, and the vast majority of attacks are also accompanied by nausea(1). During these episodes, oral therapies may be an impractical treatment option. Further, while most forms of triptans can be effective when taken early in a migraine attack, patients who experience rapid onset of migraines, or those that occur upon waking may not always achieve the fast relief they would like from tablet and nasal forms. Quickly absorbed subcutaneous sumatriptan may offer an alternative for these patients, although until now, it was only available in a needle-based system. New SUMAVEL DosePro delivers sumatriptan subcutaneously (under the skin) without a needle, which can offer fast relief in a patient-friendly delivery system.
"We are extremely pleased to announce the introduction of SUMAVEL DosePro, which represents the first needle-free subcutaneous sumatriptan available to treat acute migraines," said Stephen Farr, Ph.D., president, chief operating officer and director of Zogenix. "Given its unique attributes, SUMAVEL DosePro offers a new, fast-acting, non-oral option for patients who suffer from migraine. We believe SUMAVEL DosePro has the potential to not only replace needle-based injectable forms of sumatriptan, but also tablet and nasal triptan forms for many migraine episodes."

Zogenix and Astellas have an exclusive co-promotion agreement to market SUMAVEL DosePro needle-free delivery system in the United States. Zogenix is focusing its sales activities primarily on the neurology market while Astellas is focusing principally on primary care physicians.

*In two well-controlled clinical trials (N=1104) with patients experiencing moderate or severe pain and one or more migraine symptoms, the efficacy of subcutaneous sumatriptan versus placebo was evaluated. In these clinical trials, 16 percent of patients achieved relief within 10 minutes versus 4 percent for placebo; 70 percent of patients achieved relief at one hour versus 22 percent for placebo (P<.001); and 82 percent of patients achieved relief at two hours versus 39 percent for placebo (P<.05) [SUMAVEL DosePro prescribing information].
About SUMAVEL DosePro

SUMAVEL DosePro (sumatriptan injection) is indicated for the acute treatment of migraine attacks, with or without aura, and the acute treatment of cluster headache episodes.

SUMAVEL DosePro should only be used where a clear diagnosis of migraine or cluster headache has been established. SUMAVEL DosePro is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine and should not be administered intravenously. For a given attack, if a patient does not respond to the first dose of SUMAVEL DosePro, the diagnosis of mgraine or cluster headache should be reconsidered before administration of a second dose.

IMPORTANT SAFETY INFORMATION

SUMAVEL DosePro is contraindicated in patients with uncontrolled hypertension, in patients with history, symptoms or signs of ischemic heart disease, coronary artery vasospasm, cerebrovascular or peripheral vascular disease including ischemic bowel disease and in patients with other significant underlying cardiovascular diseases or known hypersensitivity to sumatriptan. SUMAVEL DosePro should not be given to patients in whom unrecognized coronary artery disease is predicted by the presence of risk factors without a prior cardiovascular evaluation. Serious cardiovascular events, including death, have been reported when taking sumatriptan, including patients with no findings of cardiovascular disease. Considering the extent of use of sumatriptan in patients with migraine, the incidence of these events is extremely low. Cerebrovascular events, some fatal, have been reported in patients treated with sumatriptan. In a number of cases, it appears possible that the cerebrovascular events were primary, sumatriptan having been administered in the incorrect belief the symptoms experienced were a consequence of migraine when they were not. It is important to advise patients not to administer SUMAVEL DosePro if a headache being experienced is atypical.

SUMAVEL DosePro should not be used within 24 hours of other ergotamine-containing or ergot-type medications or other 5-HT1 agonists and is not generally recommended for use with MAO-A inhibitors. The development of a potentially life-threatening serotonin syndrome may occur with triptans, including treatment with SUMAVEL DosePro, particularly during combined use with selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). SUMAVEL DosePro should be used during pregnancy only if the potential benefit justifies the potential risk.

In controlled clinical trials with sumatriptan injection, the most common adverse reactions were injection site reactions, tingling, warm/hot sensation, burning sensation, feeling of heaviness, pressure sensation, feeling of tightness, numbness, feeling strange, tight feeling in head, flushing, tightness in chest, discomfort in nasal cavity/sinuses, jaw discomfort, dizziness/vertigo, drowsiness/sedation and headache.

About DosePro Technology

The DosePro technology is an easy-to-use, pre-filled drug delivery system designed to enable self-administration of single doses of liquid drug formulations, subcutaneously, without a needle. The DosePro technology has undergone more than 10 years of design, process engineering, clinical evaluation and development work. DosePro is protected by more than 80 patents, issued and applied for, worldwide. Approximately 9,000 injections have been delivered in clinical trials in healthy volunteers using the DosePro needle-free drug delivery system.

About Zogenix

Zogenix, Inc., with offices in Emeryville and San Diego, Calif., is a privately held pharmaceutical company focused on the development and commercialization of medicines to treat neuroscience disorders and pain. The company's initial focus is the commercialization of SUMAVEL DosePro, which received U.S. Food and Drug Administration approval in July 2009. The company's pipeline also includes ZX002, a novel oral controlled-release formulation of hydrocodone without acetaminophen for the treatment of chronic pain, preparing to enter Phase 3 clinical trials. Zogenix also plans to license the patented DosePro needle-free drug delivery system to other companies.

About Astellas

Astellas Pharma U.S., Inc., located in Deerfield, Illinois, is a U.S. affiliate of Tokyo-based Astellas Pharma Inc. Astellas is a pharmaceutical company dedicated to improving the health of people around the world through the provision of innovative and reliable pharmaceutical products. The organization is committed to becoming a global category leader in focused areas by combining outstanding R&

and marketing capabilities. In the U.S., Astellas markets products in the areas of anti-infectives, cardiovascular, dermatology, immunology, neuroscience, and urology.

Zogenix™, SUMAVEL™ and DosePro™ are trademarks of Zogenix, Inc.

(1) Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache. 2001

Source: Zogenix, Inc
Article URL: Really Long Link

Main News Category: Headache / Migraine

Also Appears In: Pharma Industry / Biotech Industry, Medical Devices / Diagnostics, Clinical Trials / Drug Trials,

Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.

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Constant Pain,Everything Hurts!

February 18th 2010 20:32

Never Ending!!

With the weather being as crazy as it has been, so has my pain. I need to go to a place to be taken care of..... calm, quiet, gentle environment. I need to be able to be in the dark. The sound of a creek, soothing music.
To not answer to anyone, no responsibilities. Just for a little while. People don't get this...it's a need,not a want.
Everything hurts me. Noise, light, walking, talking. How odd when people can't get the fact that migraine is a disease. How hard it is for those of us who have it, as we fall back into the pattern of pretending we are ok when we are not.
I am never without pain. I have times when I get so drained. I couldn't fight sleep a few days ago in the day time. Later, I had an aura. My head had more pain afterward, all over the place.
I have been doing home remedies for the sinus/allergy stuff that's going on in my head. But it's been ongoing.
I need relief, I'm tired of constant pain,everything hurts!
Just as much as I need this relief, I need respect, I need understanding for what I am going through. I need support.

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treat Migraine W Cognitive Behavioral Therapy

January 6th 2010 17:41

I found this article and wow, do I wish this dr could suffer migraine/migraine attacks/chronic migraine just so he'd know how WRONG he is

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Scents in the holiday season

December 8th 2009 18:53

I have to be careful,even in the grocery store with all the stuff out for the holidays. I do wonder why they decide to put potent cinnamon scented pine cones and decorations in the fruit and vegetable section. I have gone to that section and almost got sick from the smell being so strong.
Shopping just for some new decorations, they have all the scented decorations there,too and in a few minutes I am nauseous and my head pain goes up.
I am not crazy about shopping as it is, but dealing with this makes it even harder.

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Pain and Aura starts my day

December 2nd 2009 18:42

Wanting to pull my hair out!!

I had been excited over the summer. I was able to get out and go swimming almost every day! Even in the day time. Toward the end of the summer, it was getting harder to do, and the last two weeks the pool was open, I wasn't able to go very much

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Health Problems Along With Chronic Migraine

October 24th 2009 04:08

What Happened?

So, I went to the doctor's about the pain I'm in...I wanted to have my thyroid tested, which I'm waiting for the results. When I got on the scale, I couldn't believe that I had put on almost 30 pds in less than 2 months

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How many must Die to Get Respect for Migraine Disease?

October 21st 2009 20:17

I was looking up news stories about migraine disease and found a story about a woman who was 7 months pregnant who died....was told she had a pinched nerve after going for medical help...even though her mother died of an aneurysm.
Doesn't matter where it was, Canada, the U.S. has the same sad attitude. I'm thinking it's because most migraine sufferers are women and of course women like to "be dramatic" , want attention, aren't tough like men.
This story makes me sick, it worries me as my youngest daughter is pregnant and gets really bad headaches. I will speak to her and her boyfriend about this and most likely her dr. I want them to take it seriously when she goes to the er. She has been once already, in severe pain and recently had problems breathing along with the pain

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Coping with Migraine

October 14th 2009 18:27

Easing the Pain

This is the time of year that it really starts for me...relying on coping skills. The weather changes make my pain level go up like crazy. My energy gets depleted so much just dealing with the pain

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